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Upfest was founded by three urban art-lovers and inspired by the growing number of paint jams taking place around the UK

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La+ is thought to reference the founding family, as croix translates to cross. The Lacroix family made a fortune from their simple innovation, which quickly circulated throughout Europe

Both groups were treated with the partial agonist ABT-089 orally for 5 days a week 30 min before levodopa, with each dose given for 15 weeks